When a signal peptide on a
newly synthesized protein exits from the ribosome it and the ribosome are
bound by SRP (signal recognition particle) and targeted to the translocon
(Sec61 complex) via an interaction with the SRP receptor(SRa,
SRb)
Current
Projects
Assembly and function of
the translocation machinery including the SRP
receptor, Sec61b and Sec61g.
Analysis of targeting mechanisms of proteins with tail-anchors including Sec61b and g, Vamp proteins, and the Bcl-2
family of proteins that regulate apoptosis.
